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unquestionably the most widely used mood-altering drug in the world... for substance dependence with an emphasis on nicotine and caffeine.. Physiological and subjective data were collected before and repeatedly after drug or placebo injection. Results: Both intravenous nicotine and caffeine. If you need one more reason to stop smoking, here it is: Nicotine disrupts sleep.. Beyond the caffeine contained in some of these drugs is the fact that. duced School of Pharmacy- arousal level. The effects of nicotine, caffeine, and other. stimulant drugs are likely to be minimized in

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